Article
The telomeric part of the HLA region predisposes to rheumatoid arthritis independently of the class II loci.
Human immunology - 1 Jan 2001
Zanelli E, Jones G, Pascual M, Eerligh P, van der Slik A R, Zwinderman A H, Verduyn W, Schreuder G M, Roovers E, Breedveld F C, de Vries R R, Martin J, Giphart M J
Abstract excerpt
We have evaluated the possible contribution of genes besides DQ and DR to the association of HLA with rheumatoid arthritis (RA). To this end, we have looked at the allele distributions of six microsatellites, D6S1014, D6S2673, TNFalpha, MIB, C1-2-5, and C1-3-2 among 132 RA patients and 254 controls. We have defined 19 microsatellite clusters corresponding to previously described ancestral haplotypes. One of them...
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