Article
Expression of FasL by tumor cells does not abrogate anti-tumor CTL function.
Immunology letters - 15 Feb 2004
Lee Sung-Hyung, Bar-Haim Erez, Goldberger Ofir, Reich-Zeliger Shlomit, Vadai Ezra, Tzehoval Esther, Eisenbach Lea
Abstract excerpt
The effects of Fas-ligand (FasL) expression by tumor cells on their tumorigenicity and immunogenicity have been reported as opposite, contradictory results. In some systems the killing of Fas positive cytotoxic T-cells (CTL) by FasL expressing tumors resulted in increased tumorigenicity while in other systems tumors expressing FasL were eliminated by neutrophil mediated inflammation. In the present study, we...
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