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Article

CTL adoptive immunotherapy concurrently mediates tumor regression and tumor escape.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2006

Liu Kebin, Caldwell Sheila A, Greeneltch Kristy M, Yang Dafeng, Abrams Scott I

Abstract excerpt

Tumor escape and recurrence are major impediments for successful immunotherapy. It is well-documented that the emergence of Ag-loss variants, as well as regulatory mechanisms suppressing T cell function, have been linked to inadequate antitumor activity. However, little is known regarding the role of Fas-mediated cytotoxicity by tumor-specific CD8(+) CTL in causing immune evasion of Fas resistant variants during...

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Source

Identifiers

PMID: 16517705
DOI: 10.4049/jimmunol.176.6.3374

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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