Immunotherapy via gene therapy: comparison of the effects of tumor cells transduced with the interleukin-2, interleukin-6, or interferon-gamma genes.

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Article

Immunotherapy via gene therapy: comparison of the effects of tumor cells transduced with the interleukin-2, interleukin-6, or interferon-gamma genes.

Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy - 1 Oct 1993

Porgador A, Tzehoval E, Vadai E, Feldman M, Eisenbach L

Abstract excerpt

We have comparatively analyzed the immune mechanisms induced by and the immunotherapeutic potentials of a highly metastatic clone of the Lewis lung carcinoma, D122, transduced with the interleukin-2 (IL-2), IL-6, or interferon-gamma (IFN-gamma) genes. All of the D122 cytokine gene-transduced cells induced antitumor CD8+ cytotoxic T lymphocytes (CTLs), as can be judged from in vivo depletion of CD8+ cells and in...

Topics

Animals
CD4-Positive T-Lymphocytes
Combined Modality Therapy
Genetic Therapy
Humans
Immunotherapy
Interferon-gamma
Interleukin-2
Interleukin-6
Killer Cells, Natural

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C57BL

Phenotype

T-Lymphocytes, Cytotoxic

T-Lymphocytes, Regulatory

Transduction, Genetic

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 7905286

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7905286-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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