Article
Interleukin 6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells.
Cancer research - 1 Jul 1992
Porgador A, Tzehoval E, Katz A, Vadai E, Revel M, Feldman M, Eisenbach L
Abstract excerpt
To investigate the influence of interleukin 6 (IL-6) production on malignancy of tumor cells we transfected cells of the high-metastatic, low-immunogenic D122 clone of the Lewis lung carcinoma with a mammalian expression vector containing the human IL-6 complementary DNA. In vitro, IL-6 positive transfectants showed growth inhibition that was directly correlated with the levels of IL-6 production. The in vitro...
Topics
- Adolescent
- Animals
- Humans
- Immunotherapy
- Interleukin-6
- Lung Neoplasms
- Mice
- Mice, Inbred C57BL
- Neoplasm Metastasis
- Neoplasms, Experimental
- Phenotype