Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lack of FasL-mediated killing leads to in vivo tumor promotion in mouse Lewis lung cancer.

Apoptosis : an international journal on programmed cell death - 1 Mar 2003

Lee J-K, Sayers T J, Back T C, Wigginton J M, Wiltrout R H

Abstract excerpt

Lewis lung carcinoma (3LL) cells were constitutively resistant to Fas-mediated apoptosis, but overexpression of Fas on 3LL cells allowed Fas-mediated apoptosis after crosslinking with agonist anti-Fas antibody (Jo2) in vitro. Surprisingly, Fas-overexpressing 3LL cells showed enhanced in vivo tumor progression, whereas no promotion of in vivo tumor growth was observed for dominant negative (DN) Fas-overexpressing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cross-Linking Reagents
Share to Cytoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fas Ligand Protein

Share to Genetic Vectors

Share to Interferon-gamma

Share to Membrane Glycoproteins

Share to T-Lymphocytes

Share to Up-Regulation

Source

Identifiers

PMID: 12766475
DOI: 10.1023/a:1022918625509

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lack of FasL-mediated killing leads to in vivo tumor promotion in mouse Lewis lung cancer.PMID 12766475Read ↗

Expression of FasL by tumor cells does not abrogate anti-tumor CTL function.Semantic proximity Read ↗

Anti-tumor activity of gene transfer of the membrane-stable CD40L mutant into lung cancer cells.Semantic proximity Read ↗

T-cell subset analysis of 3LL tumor growth.Semantic proximity Read ↗

Alterations in Fas expression are characteristic of, but not solely responsible for, enhanced metastatic competence.Semantic proximity Read ↗

Functional characterization of Fas ligand on tumor cells escaping active specific immunotherapy.Semantic proximity Read ↗

CD40-CD40 ligand (CD154) engagement is required but not sufficient for modulating MHC class I, ICAM-1 and Fas expression and proliferation of human non-small cell lung tumors.Semantic proximity Read ↗

In vitro susceptibility to the pro-apoptotic effects of TIMP-3 gene delivery translates to greater in vivo efficacy versus gene delivery for TIMPs-1 or -2.Semantic proximity Read ↗

Transgenic overexpression of a dominant negative mutant of FADD that, although counterselected during tumor progression, cooperates in L-myc-induced tumorigenesis.Semantic proximity Read ↗

Stromelysin-3 suppresses tumor cell apoptosis in a murine model.Semantic proximity Read ↗

Fas-independent apoptosis in T-cell tumours induced by the CD2-myc transgene.Semantic proximity Read ↗

Class I-restricted cytotoxic T lymphocytes are directly cytopathic for their target cells in vivo.Semantic proximity Read ↗

Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.