Article
A non-cleavable mutant of Fas ligand does not prevent neutrophilic destruction of islet transplants.
Transplantation - 15 May 2000
Kang S M, Braat D, Schneider D B, O'Rourke R W, Lin Z, Ascher N L, Dichek D A, Baekkeskov S, Stock P G
Abstract excerpt
BACKGROUND: Fas ligand (FasL) mediates apoptosis of susceptible Fas-expressing lymphocytes, and may contribute to the maintenance of peripheral tolerance. In transplantation models, however, artificial expression of FasL on cellular as well as islet transplants results in accelerated rejection by neutrophils. The mechanism of the neutrophilic response to FasL expression is unknown. FasL, like other members of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.