Slow repair of pyrimidine dimers at p53 mutation hotspots in skin cancer.

doi:10.1126/science.8128225

Back to search

Article

Slow repair of pyrimidine dimers at p53 mutation hotspots in skin cancer.

Science (New York, N.Y.) - 11 Mar 1994

Tornaletti S, Pfeifer G P

Abstract excerpt

Ultraviolet light has been linked with the development of human skin cancers. Such cancers often exhibit mutations in the p53 tumor suppressor gene. Ligation-mediated polymerase chain reaction was used to analyze at nucleotide resolution the repair of cyclobutane pyrimidine dimers along the p53 g...

Topics

Cells, Cultured
DNA Repair
Exons
Genes, p53
HeLa Cells
Humans
Mutation
Phosphoglycerate Kinase
Polymerase Chain Reaction
Pyrimidine Dimers
Skin
Skin Neoplasms
Ultraviolet Rays

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.