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Article

Slow repair of pyrimidine dimers at p53 mutation hotspots in skin cancer.

Science (New York, N.Y.) - 11 Mar 1994

Tornaletti S, Pfeifer G P

Abstract excerpt

Ultraviolet light has been linked with the development of human skin cancers. Such cancers often exhibit mutations in the p53 tumor suppressor gene. Ligation-mediated polymerase chain reaction was used to analyze at nucleotide resolution the repair of cyclobutane pyrimidine dimers along the p53 gene in ultraviolet-irradiated human fibroblasts. Repair rates at individual nucleotides were highly variable and...

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Identifiers

PMID: 8128225
DOI: 10.1126/science.8128225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Slow repair of pyrimidine dimers at p53 mutation hotspots in skin cancer.PMID 8128225Read ↗

UVB-induced cyclobutane pyrimidine dimer frequency correlates with skin cancer mutational hotspots in p53.Semantic proximity Read ↗

The distribution of UV photoproducts along the human p53 gene and its relation to mutations in skin cancer.Semantic proximity Read ↗

Mapping of UV photoproducts within ras proto-oncogenes in UV-irradiated cells: correlation with mutations in human skin cancer.Semantic proximity Read ↗

Sunlight induces pyrimidine dimers preferentially at 5-methylcytosine bases.Semantic proximity Read ↗

PCR-based approaches to adduct analysis.Semantic proximity Read ↗

Somatic mutation theory, DNA repair rates, and the molecular epidemiology of p53 mutations.Semantic proximity Read ↗

Site-specific analysis of UV-induced cyclobutane pyrimidine dimers in nucleotide excision repair-proficient and -deficient hamster cells: Lack of correlation with mutational spectra.Semantic proximity Read ↗

Deamination of 5-Methylcytosines within Cyclobutane Pyrimidine Dimers Is an Important Component of UVB MutagenesisSemantic proximity Read ↗

UVA-induced cyclobutane pyrimidine dimers form predominantly at thymine-thymine dipyrimidines and correlate with the mutation spectrum in rodent cells.Semantic proximity Read ↗

Human cells compromised for p53 function exhibit defective global and transcription-coupled nucleotide excision repair, whereas cells compromised for pRb function are defective only in global repairSemantic proximity Read ↗

Evidence that error-prone DNA repair converts dibenzo[a,l]pyrene-induced depurinating lesions into mutations: formation, clonal proliferation and regression of initiated cells carrying H-ras oncogene mutations in early preneoplasia.Semantic proximity Read ↗

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