Article
The distribution of UV photoproducts along the human p53 gene and its relation to mutations in skin cancer.
Oncogene - 1 Aug 1993
Tornaletti S, Rozek D, Pfeifer G P
Abstract excerpt
Mutations in the p53 gene have been found in a large proportion of human skin cancers. These mutations show the same characteristics as mutations induced by UV light in experimental systems. To establish correlations between formation of DNA adducts by a known carcinogen and incidence of mutation...
Topics
- Base Sequence
- Codon
- DNA Damage
- Exons
- Genes, p53
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Photochemistry
- Polymerase Chain Reaction
- Pyrimidine Dimers
- Skin Neoplasms