Article
Identification of genes that modify ataxin-1-induced neurodegeneration.
Nature - 2 Nov 2000
Fernandez-Funez P, Nino-Rosales M L, de Gouyon B, She W C, Luchak J M, Martinez P, Turiegano E, Benito J, Capovilla M, Skinner P J, McCall A, Canal I, Orr H T, Zoghbi H Y, Botas J
Abstract excerpt
A growing number of human neurodegenerative diseases result from the expansion of a glutamine repeat in the protein that causes the disease. Spinocerebellar ataxia type 1 (SCA1) is one such disease-caused by expansion of a polyglutamine tract in the protein ataxin-1. To elucidate the genetic pathways and molecular mechanisms underlying neuronal degeneration in this group of diseases, we have created a model...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.