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The Role of Mitochondrial DNA Copy Number in Mammalian Fertility1

3 Feb 2010

Abstract excerpt

Mammalian mitochondrial DNA (mtDNA) is a small, maternally inherited genome that codes for 13 essential proteins in the respiratory chain. Mature oocytes contain more than 150 000 copies of mtDNA, at least an order of magnitude greater than the number in most somatic cells, but sperm contain only approximately 100 copies. Mitochondrial oxidative phosphorylation has been suggested to be an important determinant of...

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PMID: 20130269
DOI: 10.1095/biolreprod.109.080887

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