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Article

Human mitochondrial transcription factor A possesses multiple subcellular targeting signals.

The FEBS journal - 1 Dec 2007

Pastukh Viktoriya, Shokolenko Inna, Wang Bin, Wilson Glenn, Alexeyev Mikhail

Abstract excerpt

The mitochondrial transcription factor A (TFAM) is a member of a high-mobility group (HMG) family represented mostly by nuclear proteins. Although nuclear localization of TFAM has been demonstrated in some tumors and after treatment of tumor cells with anticancer drugs, the significance of these observations has not been fully elucidated. Here we report that both TFAM overexpression and impairment of its...

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Source

Identifiers

PMID: 18028422
DOI: 10.1111/j.1742-4658.2007.06167.x

Genes

TFAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Human mitochondrial transcription factor A possesses multiple subcellular targeting signals.PMID 18028422Read ↗

Mitochondrial transcription factor A (TFAM) is upregulated in gliomaSemantic proximity Read ↗

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Mitochondrial transcription factor A regulates mtDNA copy number in mammalsSemantic proximity Read ↗

Tumor metastasis-associated human MTA1 gene and its MTA1 protein product: Role in epithelial cancer cell invasion, proliferation and nuclear regulationSemantic proximity Read ↗

Transcriptional activation by mitochondrial transcription factor A involves preferential distortion of promoter DNA.Semantic proximity Read ↗

UV irradiation alters TFAM binding specificity and compaction of DNASemantic proximity Read ↗

Interaction of human mitochondrial transcription factor A in mitochondria: its involvement in the dynamics of mitochondrial DNA nucleoids.Semantic proximity Read ↗

TFAM organizes DNA into compact higher order structuresSemantic proximity Read ↗

Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in MitochondriaSemantic proximity Read ↗

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Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice.Semantic proximity Read ↗

Transcription factor hStaf/ZNF143 is required for expression of the human TFAM gene.Semantic proximity Read ↗

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