Article
[Paraoxonase 1 gene Gln192Arg polymorphism in and Alzheimer disease].
Zhonghua nei ke za zhi - 1 Apr 2006
He Xiao-ming, Zhang Zhen-xin, Zhang Jun-wu, Zhou Yong-tao, Tang Mou-ni, Wu Cheng-bin, Hong Zhen
Abstract excerpt
OBJECTIVE: The aim of this study was to evaluate the association of Gln192Arg polymorphism in paraoxonase 1 (PON1) gene with Alzheimer's disease (AD) in Chinese Han population. METHODS: Gln192Arg polymorphism in PON1 gene was detected with real-time PCR (RT-PCR) technique in 521 patients with AD and 578 healthy controls. RESULTS: The presence of at least one of PON1 R allele (Q/R or R/R) was lower in AD patients...
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