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Article

Synergistic epistasis of paraoxonase 1 (rs662 and rs85460) and apolipoprotein E4 genes in pathogenesis of Alzheimer's disease and vascular dementia.

American journal of Alzheimer's disease and other dementias - 1 Dec 2014

Alam Rizwan, Tripathi Manjari, Mansoori Nasim, Parveen Shama, Luthra Kalpana, Lakshmy Ramakrishnan, Sharma Subhadra, Arulselvi Subramanian, Mukhopadhyay Asok K

Abstract excerpt

Genetic polymorphism and epistasis play a role in etiopathogenesis of Alzheimer's disease (AD) and vascular dementia (VaD). In this case-control study, a total of 241 patients were included in the study to see the effect of paraoxonase 1 (PON1; rs662 and rs85460) and apolipoprotein E (ApoE) genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alzheimer Disease
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Share to Aryldialkylphosphatase
Share to Cholesterol, HDL
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Share to Epistasis, Genetic
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Source

Open in PubMed Open full text

Identifiers

PMID: 24965284
DOI: 10.1177/1533317514539541
PMCID: PMC10852837

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24965284-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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