Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TNF-alpha promoter, Nod2 and toll-like receptor-4 polymorphisms and the in vivo and ex vivo response to endotoxin.

Cytokine - 7 Apr 2004

Schippers Emile F, van 't Veer Cornelis, van Voorden Sjaak, Martina Cerithsa A E, le Cessie Saskia, van Dissel Jaap T

Abstract excerpt

Humans exhibit substantial inter-individual differences in TNF-alpha production upon endotoxin stimulation. To determine to what extent the lipopolysaccharide-induced TNF-alpha production capacity in vivo and ex vivo is determined by polymorphisms in toll-like receptor-4 (TLR4), the TNF-alpha promoter region and Nod2, we screened for two TLR4 polymorphisms, a Nod2 polymorphism and the TNF-alpha promoter...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to In Vitro Techniques
Share to Lipopolysaccharides

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Membrane Glycoproteins

Share to Nod2 Signaling Adaptor Protein

Share to Receptors, Cell Surface

Share to Toll-Like Receptor 4

Share to Toll-Like Receptors

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 15016407
DOI: 10.1016/j.cyto.2003.12.003

Genes

TNF
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TNF-alpha promoter, Nod2 and toll-like receptor-4 polymorphisms and the in vivo and ex vivo response to endotoxin.PMID 15016407Read ↗

IL-10 and toll-like receptor-4 polymorphisms and the in vivo and ex vivo response to endotoxin.Semantic proximity Read ↗

Pre- and postoperative cytokine release after in vitro whole blood lipopolysaccharide stimulation and frequent toll-like receptor 4 polymorphisms.Semantic proximity Read ↗

The tumor necrosis factor alpha -308 G/A polymorphism does not influence inflammation and coagulation response in human endotoxemia.Semantic proximity Read ↗

Tumor necrosis factor gene polymorphism is associated with enhanced systemic inflammatory response and increased cardiopulmonary morbidity after cardiac surgery.Semantic proximity Read ↗

Alterations in leukocyte function following surgical trauma: differentiation of distinct reaction types and association with tumor necrosis factor gene polymorphisms.Semantic proximity Read ↗

Tumor necrosis factor gene polymorphisms, leukocyte function, and sepsis susceptibility in blunt trauma patients.Semantic proximity Read ↗

MMP-8 genotypes influence the inflammatory response in human endotoxemia.Semantic proximity Read ↗

Polymorphisms in or near tumour necrosis factor (TNF)-gene do not determine levels of endotoxin-induced TNF production.Semantic proximity Read ↗

The NFKB1 promoter polymorphism (-94ins/delATTG) alters nuclear translocation of NF-κB1 in monocytes after lipopolysaccharide stimulation and is associated with increased mortality in sepsis.Semantic proximity Read ↗

Common studied polymorphisms do not affect plasma cytokine levels upon endotoxin exposure in humans.Semantic proximity Read ↗

Tumor necrosis factor alpha gene variants do not display allelic imbalance in circulating myeloid cells.Semantic proximity Read ↗

TNF-α, IL-6, and IL-8 cytokines and their association with TNF-α-308 G/A polymorphism and postoperative sepsis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.