Article
Common studied polymorphisms do not affect plasma cytokine levels upon endotoxin exposure in humans.
Clinical and experimental immunology - 1 Apr 2008
Taudorf S, Krabbe K S, Berg R M G, Møller K, Pedersen B K, Bruunsgaard H
Abstract excerpt
The aim of this study was to investigate to what extent single nucleotide polymorphisms (SNPs) in promoter regions of genes of Toll-like receptor (TLR)-4, tumour necrosis factor (TNF)-alpha, interleukin (IL)-18, interferon (IFN)-gamma, IL-6 and IL-10 affect the cytokine response during a controlled low-grade inflammatory response in vivo. Two hundred healthy young male volunteers were genotyped, and cytokine...
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