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Article

IL-10 and toll-like receptor-4 polymorphisms and the in vivo and ex vivo response to endotoxin.

Cytokine - 7 Mar 2005

Schippers Emile F, van 't Veer Cornelis, van Voorden Sjaak, Martina Cerithsa A E, Huizinga Tom W J, le Cessie Saskia, van Dissel Jaap T

Abstract excerpt

To determine to what extent lipopolysaccharide-induced IL-10 production capacity is determined by polymorphisms in toll-like receptor-4 (TLR4) and the IL-10 promoter region, we measured in vivo IL-10 and TNF-alpha production in patients undergoing elective cardiopulmonary bypass surgery, a major surgical trauma associated with ischemia-reperfusion injury that triggers an endotoxemia and profound inflammatory...

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Source

Identifiers

PMID: 15760678
DOI: 10.1016/j.cyto.2004.12.005

Genes

TNF
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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