Tumor necrosis factor alpha gene variants do not display allelic imbalance in circulating myeloid cells.

doi:10.1016/j.cellimm.2010.02.004

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Tumor necrosis factor alpha gene variants do not display allelic imbalance in circulating myeloid cells.

Cellular immunology - 1 Jan 2010

Wienzek Sandra, Kissel Karin, Breithaupt Kirstin, Lang Christina, Nockher Angelika, Hackstein Holger, Bein Gregor

Abstract excerpt

Carriage of the TNF -308 A allele (rs1800629 A) has been associated with increased serum TNF-alpha levels, the development of sepsis syndrome, and fatal outcome, in severely traumatized patients (Menges et al., 2008 [1]). Herein, we analysed the putative allelic imbalance of TNF-alpha release from myeloid cells. Circulating peripheral blood cells from healthy human blood donors (n=104) and monocyte-derived...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allelic Imbalance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipopolysaccharide Receptors

Share to Monocytes

Share to Myeloid Cells

Share to Neutrophils

Share to Promoter Regions, Genetic

Share to Receptors, IgG

Share to Tumor Necrosis Factor-alpha

Source

Open in PubMed

Identifiers

PMID: 20206339
DOI: 10.1016/j.cellimm.2010.02.004

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor necrosis factor alpha gene variants do not display allelic imbalance in circulating myeloid cells.PMID 20206339Read ↗

The tumor necrosis factor alpha -308 G/A polymorphism does not influence inflammation and coagulation response in human endotoxemia.Semantic proximity Read ↗

Polymorphisms in or near tumour necrosis factor (TNF)-gene do not determine levels of endotoxin-induced TNF production.Semantic proximity Read ↗

Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans.Semantic proximity Read ↗

The tumor necrosis factor polymorphism TNF (-308) is associated with susceptibility to meningococcal sepsis, but not with lethality.Semantic proximity Read ↗

The CD14-260 C --> T promoter polymorphism co-segregates with the tumor necrosis factor-alpha (TNF-alpha)-308 G --> A polymorphism and is associated with the interleukin-1 beta (IL-1 beta) synthesis capacity of human leukocytes.Semantic proximity Read ↗

TNF-alpha promoter, Nod2 and toll-like receptor-4 polymorphisms and the in vivo and ex vivo response to endotoxin.Semantic proximity Read ↗

Common studied polymorphisms do not affect plasma cytokine levels upon endotoxin exposure in humans.Semantic proximity Read ↗

Alleles -308A and -1031C in the TNF-alpha gene promoter do not increase the risk but associated with circulating levels of TNF-alpha and clinical features of vivax malaria in Indian patients.Semantic proximity Read ↗

Polymorphism of the human TNF-alpha promoter--random variation or functional diversity?Semantic proximity Read ↗

The TNF (-308A) polymorphism is associated with microchimerism in transfused trauma patients.Semantic proximity Read ↗

-308 tumor necrosis factor (TNF) polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human TNF promoter.Semantic proximity Read ↗

Plasma interleukin-10:Tumor necrosis factor (TNF)-alpha ratio is associated with TNF promoter variants and predicts malarial complications.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.