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Article

Translational control by MAPK signaling in long-term synaptic plasticity and memory.

Cell - 6 Feb 2004

Kelleher Raymond J, Govindarajan Arvind, Jung Hae-Yoon, Kang Hyejin, Tonegawa Susumu

Abstract excerpt

Enduring forms of synaptic plasticity and memory require new protein synthesis, but little is known about the underlying regulatory mechanisms. Here, we investigate the role of MAPK signaling in these processes. Conditional expression of a dominant-negative form of MEK1 in the postnatal murine forebrain inhibited ERK activation and caused selective deficits in hippocampal memory retention and the...

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Identifiers

PMID: 15016380
DOI: 10.1016/s0092-8674(04)00115-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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