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Restoring synaptic plasticity and memory in mouse models of Alzheimer’s disease by PKR inhibition

1 Dec 2017

Abstract excerpt

Alzheimer’s disease (AD) is a neurodegenerative disorder associated with deficits in cognition and synaptic plasticity. While accumulation of amyloid β (Aβ) and hyper-phosphorylation of tau are parts of the etiology, AD can be caused by a large number of different genetic mutations and other unknown factors. Considering such a heterogeneous nature of AD, it would be desirable to develop treatment strategies that...

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PMID: 29233183
DOI: 10.1186/s13041-017-0338-3

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