Article
Compartmentalization of the MAPK scaffold protein KSR1 modulates synaptic plasticity in hippocampal neurons.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2011
Canal Frédéric, Palygin Oleg, Pankratov Yuriy, Corrêa Sônia A L, Müller Jürgen
Abstract excerpt
ERK1/2 is required for certain forms of synaptic plasticity, including the long-term potentiation of synaptic strength. However, the molecular mechanisms regulating synaptically localized ERK1/2 signaling are poorly understood. Here, we show that the MAPK scaffold protein kinase suppressor of Ras 1 (KSR1) is directly phosphorylated by the downstream kinase ERK1/2. Quantitative Western blot analysis further...
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