Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Missense Mutations of <b> <i>MADH4</i> </b>

1 Mar 2004

Abstract excerpt

PURPOSE AND EXPERIMENTAL DESIGN: The mutational spectrum of MADH4 (DPC4/SMAD4) opens valuable insights into the functions of this protein that confer its tumor-suppressive nature in human tumors. We present the MADH4 genetic status determined on a new set of pancreatic, biliary, and duodenal cancers with comparison to the mutational data reported for various tumor types. RESULTS: Homozygous deletion, followed by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic factors in colorectal cancer
Share to Pancreatic and Hepatic Oncology Research
Share to Peptidase Inhibition and Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15014009
DOI: 10.1158/1078-0432.ccr-1121-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Missense Mutations of <b> <i>MADH4</i> </b>PMID 15014009Read ↗

Functional mapping of the MH1 DNA-binding domain of DPC4/SMAD4Semantic proximity Read ↗

Identification of germline alterations of the mad homology 2 domain of SMAD3 and SMAD4 from the Ontario site of the breast cancer family registry (CFR).Semantic proximity Read ↗

SMAD4 genetic alterations predict a worse prognosis in patients with pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

Role of Smad4 (DPC4) inactivation in human cancer.Semantic proximity Read ↗

Colorectal Cancer-Associated Smad4 R361 Hotspot Mutations Boost Wnt/β-Catenin Signaling through Enhanced Smad4-LEF1 Binding.Semantic proximity Read ↗

Differential ubiquitination defines the functional status of the tumor suppressor Smad4.Semantic proximity Read ↗

Mutations at a single codon in Mad homology 2 domain of SMAD4 cause Myhre syndrome.Semantic proximity Read ↗

Unraveling the heterogeneous mutational signature of spontaneously developing tumors in MLH1 <sup>-/-</sup> miceSemantic proximity Read ↗

SMAD4 Somatic Mutations in Head and Neck Carcinoma Are Associated With Tumor ProgressionSemantic proximity Read ↗

Loss of function SMAD4 nonstop mutations in human cancer.Semantic proximity Read ↗

Nuclear localization of Dpc4 (Madh4, Smad4) in colorectal carcinomas and relation to mismatch repair/transforming growth factor-beta receptor defects.Semantic proximity Read ↗

SMAD4 MH2 Mutations Disrupt CREBBP/EP300 Recruitment and TGF-β-Induced Transcription in Colorectal CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.