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Article

Functional mapping of the MH1 DNA-binding domain of DPC4/SMAD4

15 Jun 2000

Abstract excerpt

The transcription factor Smad4 binds DNA in response to a TGF-beta ligand-initiated intracellular signaling cascade. SMAD4 is deleted or mutated during tumorigenesis in many human tumors. Some of these mutations occur in the N-terminal portion of the protein, the Mad homology 1 (MH1) region, which exhibits sequence-specific DNA-binding. We used alanine scanning mutagenesis and natural mutations to map the...

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PMID: 10871368
DOI: 10.1093/nar/28.12.2363

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