Article
Nuclear localization of Dpc4 (Madh4, Smad4) in colorectal carcinomas and relation to mismatch repair/transforming growth factor-beta receptor defects.
The American journal of pathology - 1 Feb 2001
Montgomery E, Goggins M, Zhou S, Argani P, Wilentz R, Kaushal M, Booker S, Romans K, Bhargava P, Hruban R, Kern S
Abstract excerpt
The tumor-suppressor protein Dpc4 (Smad4, Madh4) regulates gene expression. On binding of an extracellular ligand of the extensive transforming growth factor (TGF) superfamily to its cognate receptor complex, latent cytoplasmic Dpc4 is activated and translocated into the nucleus to function as part of various DNA-binding transcriptional activator complexes. The most relevant ligand/receptor pair to control the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.