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Article

SMAD4 Somatic Mutations in Head and Neck Carcinoma Are Associated With Tumor Progression

6 Dec 2019

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) incidence and mortality rate have been increasing worldwide. Therefore, understanding the genomic alterations involved in HNSCC carcinogenesis is a crucial issue for HNSCC diagnosis and therapy. The tumor suppressor gene SMAD4 (DPC4) at chromosome 18q21.1 belongs to the SMAD family, which mediates the TGF-β signaling pathway that suppresses epithelial cell growth. In...

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PMID: 31867281
DOI: 10.3389/fonc.2019.01379

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