Article
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.
The Journal of biological chemistry - 24 Mar 2000
Fang S, Jensen J P, Ludwig R L, Vousden K H, Weissman A M
Abstract excerpt
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation. We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its activity is dependent on its RING finger. Furthermore, we show that Mdm2 mediates its own ubiquitination in a RING finger-dependent manner, which requires no eukaryotic proteins other than ubiquitin-activating enzyme (E1) and an...
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