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Article

Inactivation of the MDM2 RING domain enhances p53 transcriptional activity in mice.

The Journal of biological chemistry - 29 Dec 2017

Tian Hui, Tackmann Nicole R, Jin Aiwen, Zheng Junnian, Zhang Yanping

Abstract excerpt

The MDM2 RING domain harbors E3 ubiquitin ligase activity critical for regulating the degradation of tumor suppressor p53, which controls many cellular pathways. The MDM2 RING domain also is required for an interaction with MDMX. Mice containing a substitution in the MDM2 RING domain, MDM2C462A, disrupting MDM2 E3 function and the MDMX interaction, die during early embryogenesis that can be rescued by p53...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-mdm2

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Source

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Identifiers

PMID: 29123033
DOI: 10.1074/jbc.RA117.000122
PMCID: PMC5766955

Genes

MDM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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