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Article

The acetylase activity of p300 is dispensable for MDM2 stabilization.

The Journal of biological chemistry - 28 Feb 2003

Zeng Shelya X, Jin Yetao, Kuninger David T, Rotwein Peter, Lu Hua

Abstract excerpt

It has been shown that p300 binds to MDM2 and leads to down-regulation of the p53 function. However, it remains unclear whether the acetylase activity of p300 is necessary for regulating MDM2 stability. In this study, we address this issue. First, p300 did not acetylate MDM2 in solution and in cells. Second, overexpression of p300 in cells increased the level of the MDM2 protein but not its mRNA. Similarly, the...

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Source

Identifiers

PMID: 12493762
DOI: 10.1074/jbc.M209030200

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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