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Article

Evaluation of HFE (hemochromatosis) mutations as genetic modifiers in sporadic AD and MCI.

Neurobiology of aging - 1 Apr 2004

Berlin Daniel, Chong George, Chertkow Howard, Bergman Howard, Phillips Natalie A, Schipper Hyman M

Abstract excerpt

BACKGROUND: Pathological brain iron deposition has been implicated as a source of neurotoxic reactive oxygen species in Alzheimer disease (AD). Recent reports suggest that heterozygosity for the two common hfe mutations responsible for hereditary hemochromatosis (HH) may be a risk factor for AD, possibly by accelerating brain iron accumulation. METHODS: To test this hypothesis, we genotyped 213 sporadic AD, 106...

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Source

Identifiers

PMID: 15013567
DOI: 10.1016/j.neurobiolaging.2003.06.008

Genes

HFE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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