Article
The hemochromatosis gene affects the age of onset of sporadic Alzheimer's disease.
Neurobiology of aging - 1 Jan 2000
Sampietro M, Caputo L, Casatta A, Meregalli M, Pellagatti A, Tagliabue J, Annoni G, Vergani C
Abstract excerpt
In the present study we analysed the genotype of HFE, the gene involved in hemochromatosis, in 107 patients with sporadic late-onset AD and in 99 age-matched non-demented controls. We observed that patients carrying the mutant HFE-H63D allele had a mean age at onset of 71.7 +/- 6.0 years versus 76.6 +/- 5.8 years of those who were homozygous for the wild-type allele (p = 0.001). The frequency of the HFE-H63D...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.