Article
Are hereditary hemochromatosis mutations involved in Alzheimer disease?
American journal of medical genetics - 3 Jul 2000
Moalem S, Percy M E, Andrews D F, Kruck T P, Wong S, Dalton A J, Mehta P, Fedor B, Warren A C
Abstract excerpt
Mutations in the class I-like major histocompatibility complex gene called HFE are associated with hereditary hemochromatosis (HHC), a disorder of excessive iron uptake. We screened DNA samples from patients with familial Alzheimer disease (FAD) (n = 26), adults with Down syndrome (DS) (n = 50), and older (n = 41) and younger (n = 52) healthy normal individuals, for two HHC point mutations-C282Y and H63D. Because...
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