Article
A genome-wide scan for linkage to chromosomal regions in 382 sibling pairs with schizophrenia or schizoaffective disorder.
The American journal of psychiatry - 1 May 2002
DeLisi Lynn E, Shaw Sarah H, Crow Timothy J, Shields Gail, Smith Angela B, Larach Veronica W, Wellman Nigel, Loftus Josephine, Nanthakumar Betsy, Razi Kamran, Stewart John, Comazzi Margherita, Vita Antonio, Heffner Thomas, Sherrington Robin
Abstract excerpt
OBJECTIVE: Some genome-wide scans and association studies for schizophrenia susceptibility genes have yielded significant positive findings, but there is disagreement between studies on their locations, and no mutation has yet been found in any gene. Since schizophrenia is a complex disorder, a study with sufficient power to detect a locus with a small or moderate gene effect is necessary. METHOD: In a...
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