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Article

Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22.

Science (New York, N.Y.) - 28 Apr 2000

Brzustowicz L M, Hodgkinson K A, Chow E W, Honer W G, Bassett A S

Abstract excerpt

Schizophrenia is a complex disorder, and there is substantial evidence supporting a genetic etiology. Despite this, prior attempts to localize susceptibility loci have produced predominantly suggestive findings. A genome-wide scan for schizophrenia susceptibility loci in 22 extended families with high rates of schizophrenia provided highly significant evidence of linkage to chromosome 1 (1q21-q22), with a maximum...

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Identifiers

PMID: 10784452
DOI: 10.1126/science.288.5466.678
PMCID: PMC3787922

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