Article
Search for a schizophrenia susceptibility locus on human chromosome 22.
American journal of medical genetics - 15 Jun 1994
Polymeropoulos M H, Coon H, Byerley W, Gershon E S, Goldin L, Crow T J, Rubenstein J, Hoff M, Holik J, Smith A M
Abstract excerpt
We used 10 highly informative DNA polymorphic markers and genetic linkage analysis to examine whether a gene locus predisposing to schizophrenia is located on chromosome 22, in 105 families with schizophrenia and schizoaffective disorder. The LOD score method, including analysis for heterogeneity, provided no conclusive evidence of linkage under a dominant, recessive, or penetrance free model of inheritance....
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