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Article

Gain of chromosome 21 or amplification of chromosome arm 21q is one mechanism for increased ERG expression in acute myeloid leukemia.

Genes, chromosomes & cancer - 1 Feb 2016

Weber Simone, Haferlach Claudia, Jeromin Sabine, Nadarajah Niroshan, Dicker Frank, Noël Louisa, Zenger Melanie, Alpermann Tamara, Kern Wolfgang, Haferlach Torsten, Schnittger Susanne

Abstract excerpt

In acute myeloid leukemia (AML), acquired genomic gains and losses are common and lead to altered expression of genes located within or nearby the affected regions. Increased expression of the ETS-related transcription factor gene ERG has been described in myeloid malignancies with chromosomal rearrangements involving chromosome band 21q22, but also in cytogenetically normal AML, where it is associated with...

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Share to Chromosome Duplication
Share to Chromosomes, Human, Pair 21

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Comparative Genomic Hybridization

Share to Core Binding Factor Alpha 2 Subunit

Share to Gene Amplification

Share to Leukemia, Myeloid, Acute

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Share to Transcriptional Regulator ERG

Source

Identifiers

PMID: 26542308
DOI: 10.1002/gcc.22321

Genes

ERG
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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