Article
Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias.
Leukemia - 1 Apr 2015
Tursky M L, Beck D, Thoms J A I, Huang Y, Kumari A, Unnikrishnan A, Knezevic K, Evans K, Richards L A, Lee E, Morris J, Goldberg L, Izraeli S, Wong J W H, Olivier J, Lock R B, MacKenzie K L, Pimanda J E
Abstract excerpt
High expression of the ETS family transcription factor ERG is associated with poor clinical outcome in acute myeloid leukemia (AML) and acute T-cell lymphoblastic leukemia (T-ALL). In murine models, high ERG expression induces both T-ALL and AML. However, no study to date has defined the effect of high ERG expression on primary human hematopoietic cells. In the present study, human CD34+ cells were transduced...
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