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Article

Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia

24 Aug 2013

Abstract excerpt

The ETS transcription factor ERG plays a central role in definitive hematopoiesis, and its overexpression in acute myeloid leukemia (AML) is associated with a stem cell signature and poor prognosis. Yet how ERG causes leukemia is unclear. Here we show that pan-hematopoietic ERG expression induces an early progenitor myeloid leukemia in transgenic mice. Integrated genome-scale analysis of gene expression and ERG...

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Identifiers

PMID: 23974202
DOI: 10.1182/blood-2013-01-477133

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Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemiaPMID 23974202Read ↗

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