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Article

High Expression of the ETS Transcription Factor <i>ERG</i> Predicts Adverse Outcome in Acute T-Lymphoblastic Leukemia in Adults

6 Sept 2006

Abstract excerpt

PURPOSE: In adult T-lymphoblastic leukemia (T-ALL) disease-free survival remains limited to 32% to 46%. The adverse prognosis in T-ALL has not been attributed to cytogenetic or molecular aberrations. We have determined the prognostic impact of the oncogenic transcription factor ERG in T-ALL. PATIENTS AND METHODS: ERG expression was analyzed by real-time polymerase chain reaction (PCR) in 105 adults with newly...

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PMID: 16954520
DOI: 10.1200/jco.2006.06.1580

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