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Article

Complex genomic alterations and gene expression in acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21.

Proceedings of the National Academy of Sciences of the United States of America - 23 May 2006

Strefford Jon C, van Delft Frederik W, Robinson Hazel M, Worley Helen, Yiannikouris Olga, Selzer Rebecca, Richmond Todd, Hann Ian, Bellotti Tony, Raghavan Manoj, Young Bryan D, Saha Vaskar, Harrison Christine J

Abstract excerpt

We have previously identified a unique subtype of acute lymphoblastic leukemia (ALL) associated with a poor outcome and characterized by intrachromosomal amplification of chromosome 21 including the RUNX1 gene (iAMP21). In this study, array-based comparative genomic hybridization (aCGH) (n = 10) detected a common region of amplification (CRA) between 33.192 and 39.796 Mb and a common region of deletion (CRD)...

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Share to Genome
Share to Chromosome Aberrations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Artificial, Bacterial

Share to Chromosomes, Human, Pair 21

Share to Genome, Human

Share to In Situ Hybridization, Fluorescence

Share to Oligonucleotide Array Sequence Analysis

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Open in PubMed Open full text

Identifiers

PMID: 16702559
DOI: 10.1073/pnas.0602360103
PMCID: PMC1472447

Genes

RUNX1
ETV6
LGMN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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