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Novel high-risk acute myeloid leukemia subgroup with ERG amplification and Biallelic loss of TP53.

Cancer genetics - 1 Apr 2023

Schandl Cynthia A, Mazzoni Sandra, Znoyko Iya, Nahhas Georges J, Chung Dongjun, Ding Yanna, Hess Brian, Wolff Daynna J

Abstract excerpt

ETS-related gene (ERG) amplification, observed in 4-6% of acute myeloid leukemia (AML), is associated with unfavorable prognosis. To determine coincident effects of additional genomic abnormalities in AML with ERG amplification (ERGamp), we examined 11 ERGamp cases of 205 newly diagnosed AML using chromosomal microarray analysis and next generation sequencing. ERGamp cases demonstrated a distinct pattern of high...

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Share to In Situ Hybridization, Fluorescence
Share to Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Transcriptional Regulator ERG

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Identifiers

PMID: 36657266
DOI: 10.1016/j.cancergen.2023.01.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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