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Article

p53-R273H gains new function in induction of drug resistance through down-regulation of procaspase-3.

Molecular cancer therapeutics - 1 Mar 2007

Wong Ronald Pak Cheung, Tsang Wing Pui, Chau Pui Yee, Co Ngai Na, Tsang Tsun Yee, Kwok Tim Tak

Abstract excerpt

Development of drug resistance is one of the major obstacles in cancer chemotherapy. The molecular mechanism leading to drug resistance is still not fully understood. A10A cells, a doxorubicin-resistant subline of human squamous cell carcinoma A431 cells, showed cross-resistance to methotrexate and also resistance to the drug-induced apoptosis. The cells also showed overexpression of a mutated form of p53,...

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Source

Identifiers

PMID: 17363498
DOI: 10.1158/1535-7163.MCT-06-0336

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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