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Article

Characterization of the functional insulin binding epitopes of the full-length insulin receptor.

The Journal of biological chemistry - 3 Jun 2005

Whittaker Jonathan, Whittaker Linda

Abstract excerpt

Mutational analyses of the secreted recombinant insulin receptor extracellular domain have identified a ligand binding site composed of residues located in the L1 domain (amino acids 1-470) and at the C terminus of the alpha subunit (amino acids 705-715). To evaluate the physiological significance of this ligand binding site, we have transiently expressed cDNAs encoding full-length receptors with alanine...

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PMID: 15799978
DOI: 10.1074/jbc.M411320200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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