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Article

Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA.

The EMBO journal - 17 May 2006

Ringvoll Jeanette, Nordstrand Line M, Vågbø Cathrine B, Talstad Vivi, Reite Karen, Aas Per Arne, Lauritzen Knut H, Liabakk Nina Beate, Bjørk Alexandra, Doughty Richard William, Falnes Pål Ø, Krokan Hans E, Klungland Arne

Abstract excerpt

Two human homologs of the Escherichia coli AlkB protein, denoted hABH2 and hABH3, were recently shown to directly reverse 1-methyladenine (1meA) and 3-methylcytosine (3meC) damages in DNA. We demonstrate that mice lacking functional mABH2 or mABH3 genes, or both, are viable and without overt phenotypes. Neither were histopathological changes observed in the gene-targeted mice. However, in the absence of any...

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Identifiers

PMID: 16642038
DOI: 10.1038/sj.emboj.7601109
PMCID: PMC1462979

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