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Article

The MTHFR C677T and A1298C polymorphisms and susceptibility to childhood acute lymphoblastic leukemia in Portugal.

Journal of pediatric hematology/oncology - 1 Aug 2005

Oliveira Elisabete, Alves Sandra, Quental Sofia, Ferreira Fátima, Norton Lucília, Costa Vitor, Amorim António, Prata Maria João

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme in folate metabolism and in DNA methylation and synthesis. The role of two common polymorphisms at the MTHFR gene, C677T and A1298C, in the etiology of childhood or adult acute lymphoblastic leukemia (ALL) has been previously investigated. Although a protective effect of MTHFR*677T against ALL was systematically reported, the magnitude of the...

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Identifiers

PMID: 16096524
DOI: 10.1097/01.mph.0000177513.81465.94

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The MTHFR C677T and A1298C polymorphisms and susceptibility to childhood acute lymphoblastic leukemia in Portugal.PMID 16096524Read ↗

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