Article
Lack of association between MTHFR C677T and A1298C polymorphisms and risk of childhood acute lymphoblastic leukemia in the Kurdish population from Western Iran.
Genetic testing and molecular biomarkers - 1 Mar 2012
Azhar Mohammad-Reza, Rahimi Zohreh, Vaisi-Raygani Asad, Akramipour Reza, Madani Hamid, Rahimi Ziba, Parsian Abbas
Abstract excerpt
AIMS: Polymorphism in genes involved in folate metabolism may influence the susceptibility to acute lymphoblastic leukemia (ALL). The aim of the present study was to determine the role of the two most common polymorphisms of the 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene, MTHFR C677T and A1298C, and their interaction on the susceptibility to ALL. METHODS: Seventy-two children with ALL and 109 age- and...
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