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Article

Tracing conformational transition of abnormal prion proteins during interspecies transmission by using novel antibodies.

The Journal of biological chemistry - 16 Apr 2010

Ushiki-Kaku Yuko, Endo Ryo, Iwamaru Yoshifumi, Shimizu Yoshihisa, Imamura Morikazu, Masujin Kentaro, Yamamoto Takuji, Hattori Shunji, Itohara Shigeyoshi, Irie Shinkichi, Yokoyama Takashi

Abstract excerpt

Conformational differences in abnormal prion proteins (PrP(Sc)) have been postulated to produce different prion phenotypes. During the interspecies transmission of prions, the conformation of PrP(Sc) may change with passage; however, little is known about the mechanism of PrP(Sc) transition. In t...

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Identifiers

PMID: 20177064
DOI: 10.1074/jbc.M109.058859
PMCID: PMC2852930

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20177064-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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