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Article

Heterogeneity of normal prion protein in two‐dimensional immunoblot: presence of various glycosylated and truncated forms

21 May 2002

Abstract excerpt

The common use of one-dimensional (1-D) immunoblot with a single monoclonal antibody (Mab) engenders the notion that the normal or cellular prion protein (PrP(C) ) comprises few and simple forms. In this study we used two-dimensional (2-D) immunoblot with a panel Mabs to various regions of the prion protein to demonstrate the complexity of the PrP(C) present in human brain. We distinguished over 50 immunoblot...

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PMID: 12065622
DOI: 10.1046/j.1471-4159.2002.00909.x

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