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Article

PrPSc-Specific Antibody Reveals C-Terminal Conformational Differences between Prion Strains.

Journal of virology - 15 May 2016

Saijo Eri, Hughson Andrew G, Raymond Gregory J, Suzuki Akio, Horiuchi Motohiro, Caughey Byron

Abstract excerpt

UNLABELLED: Understanding the structure of PrP(Sc) and its strain variation has been one of the major challenges in prion disease biology. To study the strain-dependent conformations of PrP(Sc), we purified proteinase-resistant PrP(Sc) (PrP(RES)) from mouse brains with three different murine-adapted scrapie strains (Chandler, 22L, and Me7) and systematically tested the accessibility of epitopes of a wide range of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26937029
DOI: 10.1128/JVI.00088-16
PMCID: PMC4859706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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