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Article

Structural requirements for mutational lutropin/choriogonadotropin receptor activation.

The Journal of biological chemistry - 6 Dec 2002

Sangkuhl Katrin, Schulz Angela, Schultz Günter, Schöneberg Torsten

Abstract excerpt

Different activation mechanisms of glycoprotein hormone receptors, which are members of the G protein-coupled receptor superfamily, have been proposed. For example, the large ectodomain of glycoprotein hormone receptors may function as an inverse agonist keeping the transmembrane domain in an inactive conformation. To provide support for this hypothesis, we have generated different lutropin/choriogonadotropin...

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PMID: 12356766
DOI: 10.1074/jbc.M203491200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Structural requirements for mutational lutropin/choriogonadotropin receptor activation.PMID 12356766Read ↗

Differences in Signal Activation by LH and hCG are Mediated by the LH/CG Receptor’s Extracellular Hinge RegionSemantic proximity Read ↗

Mutations that induce constitutive activation and mutations that impair signal transduction modulate the basal and/or agonist-stimulated internalization of the Lutropin/Choriogonadotropin receptor.Semantic proximity Read ↗

Constitutively Activating Mutants of Equine LH/CGR Constitutively Induce Signal Transduction and Inactivating Mutations Impair Biological Activity and Cell-Surface Receptor Loss In Vitro.Semantic proximity Read ↗

Effect of activating and inactivating mutations on the phosphorylation and trafficking of the human lutropin/choriogonadotropin receptor.Semantic proximity Read ↗

Contributions of intracellular loops 2 and 3 of the lutropin receptor in Gs coupling.Semantic proximity Read ↗

The formation of a salt bridge between helices 3 and 6 is responsible for the constitutive activity and lack of hormone responsiveness of the naturally occurring L457R mutation of the human lutropin receptor.Semantic proximity Read ↗

Asp330 and Tyr331 in the C-terminal cysteine-rich region of the luteinizing hormone receptor are key residues in hormone-induced receptor activation.Semantic proximity Read ↗

Structural and functional plasticity of the luteinizing hormone/choriogonadotrophin receptor.Semantic proximity Read ↗

Constitutive activity in gonadotropin receptors.Semantic proximity Read ↗

Activating mutations of the lutropin choriogonadotropin receptor in precocious puberty.Semantic proximity Read ↗

A molecular dissection of the glycoprotein hormone receptors.Semantic proximity Read ↗

Mutations in Conserved Regions of Eel Luteinizing Hormone Receptor Result in Constitutive Activation or InactivationSemantic proximity Read ↗

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