Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Principles and determinants of G-protein coupling by the rhodopsin-like thyrotropin receptor.

PloS one - 18 Mar 2010

Kleinau Gunnar, Jaeschke Holger, Worth Catherine L, Mueller Sandra, Gonzalez Jorge, Paschke Ralf, Krause Gerd

Abstract excerpt

In this study we wanted to gain insights into selectivity mechanisms between G-protein-coupled receptors (GPCR) and different subtypes of G-proteins. The thyrotropin receptor (TSHR) binds G-proteins promiscuously and activates both Gs (cAMP) and Gq (IP). Our goal was to dissect selectivity patterns for both pathways in the intracellular region of this receptor. We were particularly interested in the participation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to Cell Separation
Share to Chlorocebus aethiops

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP

Share to Inositol Phosphates

Share to Receptors, G-Protein-Coupled

Share to Rhodopsin

Share to Thyrotropin

Source

Open in PubMed Open full text

Identifiers

PMID: 20305779
DOI: 10.1371/journal.pone.0009745
PMCID: PMC2841179

Genes

TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Principles and determinants of G-protein coupling by the rhodopsin-like thyrotropin receptor.PMID 20305779Read ↗

Thyrotropin and Homologous Glycoprotein Hormone Receptors: Structural and Functional Aspects of Extracellular Signaling MechanismsSemantic proximity Read ↗

Structural determinants for g protein activation and selectivity in the second intracellular loop of the thyrotropin receptor.Semantic proximity Read ↗

Novel insights on thyroid-stimulating hormone receptor signal transduction.Semantic proximity Read ↗

Molecular and structural effects of inverse agonistic mutations on signaling of the thyrotropin receptor--a basally active GPCR.Semantic proximity Read ↗

The intramolecular agonist is obligate for activation of glycoprotein hormone receptors.Semantic proximity Read ↗

Thyrotropin receptor, still much to be learned from the patients.Semantic proximity Read ↗

Thyrotropin receptor mutations as a tool to understand thyrotropin receptor action.Semantic proximity Read ↗

From molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduction in family a G-protein-coupled receptors (GPCRs).Semantic proximity Read ↗

Minireview: Structural and Functional Evolution of the Thyrotropin ReceptorSemantic proximity Read ↗

An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor.Semantic proximity Read ↗

Extended and Structurally Supported Insights into Extracellular Hormone Binding, Signal Transduction and Organization of the Thyrotropin ReceptorSemantic proximity Read ↗

Influence of the hinge region and its adjacent domains on binding and signaling patterns of the thyrotropin and follitropin receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.